Rupatadine and Levocetirizine for Seasonal Allergic Rhinitis

• DOI: 10.1001/archoto.2010.128
• Publication Date: 2010-08-16T20:14:28Z
• Authors: Rituparna Maiti; Jalelur Rahman; Jyothirmai Jaida; Uma Allala; Anuradha Palani
• Keywords: Levocetirizine

<h3>Objective</h3> To determine the better agent among rupatadine fumarate and levocetirizine dihydrochloride for seasonal allergic rhinitis. Although treating ensuring a decent quality of life to patients is challenging, an increasing understanding pathomechanisms has revealed potentiality new-generation antihistamines in treatment <h3>Design</h3> A 2-week, single-center, randomized, open, parallel group comparative clinical study between with <h3>Setting</h3> tertiary care center. <h3>Patients</h3> Following inclusion exclusion criteria, 60 were assigned either or group. <h3>Interventions</h3> Two-week levocetirizine. <h3>Main Outcome Measures</h3> After 2 weeks, all postdrug symptoms listed, baseline laboratory investigations (total differential leukocyte count IgE level) repeated, improvement was assessed terms change Total Nasal Symptom Score, Rhinoconjunctivitis Quality Life Questionnaire score, parameters. <h3>Results</h3> Differential (<i>P</i> = .01) absolute eosinophil .009) significantly lowered by both drugs, but found be superior. In there higher reduction .004) level Score &lt; .001) compared There decrease 18.08% .02) score group, which greater Incidence adverse effects less <h3>Conclusion</h3> Rupatadine choice rhinitis because its efficacy safety profile.