Measurement of Urinary S100B Protein Concentrations for the Early Identification of Brain Damage in Asphyxiated Full-term Infants

• DOI: 10.1001/archpedi.157.12.1163
• Publication Date: 2003-12-08T21:39:09Z
• Authors: Diego Gazzolo; Emanuela Marinoni; Romolo Di Iorio; Matteo Bruschettini; Maria Kornacka; Mario Lituania; Urszula Majewska; Giovanni Serra; Fabrizio Michetti
• Keywords: Urination; Perinatal asphyxia; Brain damage; Full Term; Neonatology

<h3>Background</h3> Perinatal asphyxia is a major cause of mortality and morbidity. To date there are no reliable methods to detect which infants will develop brain damage after insult. We investigated whether measurements urine levels S100B in asphyxiated full-term newborns may be useful tool for early detection postasphyxia damage. <h3>Methods</h3> A prospective study 38 with perinatal 96 control subjects, recruited at 3 tertiary departments neonatology between April 1, 1999, July 31, 2001. Routine laboratory variables, neurologic patterns, concentrations protein were determined 4 predetermined time points (first urination 12, 24, 72 hours birth). The measured using an immunoluminometric assay. results correlated the presence or absence abnormalities age 12 months. <h3>Results</h3> significantly higher samples collected all monitoring times from new-borns abnormal findings on follow-up urination, 1.92 ± 0.33 µg/L; hours, 2.78 1.71 24 4.75 4.08 5.93 1.63 µg/L) than those without 0.24 0.06 0.13 0.21 0.07 0.12 0.04 healthy 0.11 0.01 0.03 0.02 (<i>P</i>&lt;.001 all). An concentration cutoff 0.28 µg/L first had sensitivity 100% specificity 87.3% predicting development follow-up. obtained up 98.2%, respectively. <h3>Conclusion</h3> Longitudinal soon birth identify risk long-term sequelae.