A Follow-up Magnetic Resonance Imaging Study of Schizophrenia

• DOI: 10.1001/archpsyc.55.2.145
• Publication Date: 2003-03-18T16:45:16Z
• Authors: Raquel E. Gur; Patricia Cowell; Bruce I. Turetsky; Fiona Gallacher; Tyrone Cannon; Warren Bilker; Ruben C. Gur
• Keywords: Frontal lobe

Cross-sectional neuroanatomical studies have reported abnormalities in schizophrenia that relate to disease variables. Longitudinal neuroimaging investigations integrate anatomical, clinical, and neurobehavioral measures may help clarify the pathogenesis of schizophrenia.Magnetic resonance brain imaging were conducted at baseline after 30.63 +/- 12.92 months (mean SD) 40 patients with (23 men 17 women) healthy controls (13 4 women). The group included 20 first-episode previously treated subjects. Volumes whole-brain, cerebrospinal fluid, frontal temporal lobes measured. severity negative positive symptoms was assessed, medications monitored, functioning 8 domains evaluated.Both had smaller brains than intake. Longitudinally, reduction lobe volume found only patients, whereas also seen controls. association between symptom changes differed patient groups, but associated decline some functions both groups. Exploratory analysis suggested neuroleptic dose is correlated all 3 domains.The existence indicates dysfunction occurred before clinical presentation. However, there evidence progression, which anatomical affect features illness patients.