Association of Neonatal Hypoglycemia With Academic Performance in Mid-Childhood

• DOI: 10.1001/jama.2022.0992
• Publication Date: 2022-03-22T11:01:40Z
• Authors: Rajesh Shah; Darren W. T. Dai; Jane M. Alsweiler; Gavin T. L. Brown; J. Geoffrey Chase; Gregory D. Gamble; Deborah L. Harris; Peter Keegan; Samson Nivins; Trecia A. Wouldes; Benjamin Thompson; Jason Turuwhenua; Jane E. Harding; Christopher J. D....; ; Heidi Feldman; William Hay; Robert Hess; Darrell Wilson; Jenny Rogers; Steven Miller; Eleanor Kennedy; Arijit Chakraborty; Jennifer Knopp; Tony Zhou; Jocelyn Ledger; Stephanie Macdonald; Alecia McNeill; Coila Bevan; Nataliia Burakevych; Robyn May; Safayet Hossin; Grace McKnight; Rashedul Hasan; Jessica Wilson
• Keywords: Neonatal hypoglycemia

Neonatal hypoglycemia is associated with increased risk of poor executive and visual-motor function, but implications for later learning are uncertain.To test the hypothesis that neonatal educational performance at age 9 to 10 years.Prospective cohort study moderate late preterm term infants born hypoglycemia. Blood masked interstitial sensor glucose concentrations were measured up 7 days. Infants hypoglycemic episodes (blood concentration <47 mg/dL [2.6 mmol/L]) treated maintain a blood least 47 mg/dL. Six hundred fourteen recruited Waikato Hospital, Hamilton, New Zealand, in 2006-2010; 480 assessed years 2016-2020.Hypoglycemia was defined as 1 event, representing sum nonconcurrent (sensor ≥10 minutes) more than 20 minutes apart.The primary outcome low achievement, performing below or well normative curriculum level standardized tests reading comprehension mathematics. There secondary outcomes related psychosocial adaptation, general health.Of 587 eligible children (230 [48%] female), (82%) mean 9.4 (SD, 0.3) years. Children who not exposed did significantly differ on rates achievement (138/304 [47%] vs 82/176 [48%], respectively; adjusted difference, -2% [95% CI, -11% 8%]; relative risk, 0.95 0.78-1.15]). hypoglycemia, compared those exposed, less likely be rated by teachers being (68/281 [24%] 49/157 [31%], -9% -17% -1%]; 0.72 0.53-0.99; P = .04]). Groups different other end points.Among participants screened if needed, exposure no such lower mid-childhood.