Association of COVID-19 vs Influenza With Risk of Arterial and Venous Thrombotic Events Among Hospitalized Patients

• DOI: 10.1001/jama.2022.13072
• Publication Date: 2022-08-16T15:03:36Z
• Authors: Vincent Lo Re; Sarah K. Dutcher; John G. Connolly; Silvia Perez-Vilar; Dean M. Carbonari; Terese A. DeFor; Djeneba Audrey Djibo; Laura B. Harrington; Laura Hou; Sean Hennessy; Rebecca A. Hubbard; Maria E. Kempner; Jennifer L. Kuntz; Cheryl N. McMahil...; Jolene Mosley; Pamala A. Pawloski; Andrew B. Petrone; Allyson M. Pishko; Meighan Rogers Dr...; Claudia A. Steiner; Yunping Zhou; Noelle M. Cocoros
• Keywords: Aged, 80 and over; Male; Risk; COVID-19 Vaccines; Incidence; Myocardial Infarction; COVID-19; Thrombosis; Middle Aged; Risk Assessment; 3. Good health; Hospitalization; Thromboembolism; Influenza, Human; Humans; Female; Public Health Surveillance; Pulmonary Embolism; Aged; Ischemic Stroke; Retrospective Studies

Importance The incidence of arterial thromboembolism and venous in persons with COVID-19 remains unclear. Objective To measure the 90-day risk patients hospitalized before or during vaccine availability vs influenza. Design, Setting, Participants Retrospective cohort study 41 443 (April-November 2020), 44 194 (December 2020-May 2021), 8269 influenza (October 2018-April 2019) US Food Drug Administration Sentinel System (data from 2 national health insurers 4 regional integrated systems). Exposures (identified by hospital diagnosis nucleic acid test). Main Outcomes Measures Hospital (acute myocardial infarction ischemic stroke) (deep vein thrombosis pulmonary embolism) within 90 days. were ascertained through July 2019 for August 2021 COVID-19. Propensity scores fine stratification developed to account differences between cohorts. Weighted Cox regression was used estimate adjusted hazard ratios (HRs) outcomes each period period. Results A total 85 637 (mean age, 72 [SD, 13.0] years; 50.5% male) 13.3] 45.0% included. absolute 14.4% (95% CI, 13.6%-15.2%) 15.8% 15.5%-16.2%) (risk difference, 1.4% [95% 1.0%-2.3%]) 16.3% 16.0%-16.6%) 1.9% 1.1%-2.7%]). Compared influenza, not significantly higher among (adjusted HR, 1.04 0.97-1.11]) 1.07 1.00-1.14]). 5.3% 4.9%-5.8%) 9.5% 9.2%-9.7%) 4.1% 3.6%-4.7%]) 10.9% 10.6%-11.1%) 5.5% 5.0%-6.1%]). 1.60 1.43-1.79]) 1.89 1.68-2.12]). Conclusions Relevance Based on data a public surveillance system, hospitalization availability, 2018-2019, associated days, but there no significant difference