Analysis of Psychological Symptoms Following Disclosure of Amyloid–Positron Emission Tomography Imaging Results to Adults With Subjective Cognitive Decline
Depression
Cognitive Decline
Amyloid (mycology)
DOI:
10.1001/jamanetworkopen.2022.50921
Publication Date:
2023-01-13T16:15:26Z
AUTHORS (320)
ABSTRACT
Importance Individuals who are amyloid-positive with subjective cognitive decline and clinical features increasing the likelihood of preclinical Alzheimer disease (SCD+) at higher risk developing dementia. Some individuals SCD+ undergo amyloid-positron emission tomography (PET) as part research studies frequently wish to know their amyloid status; however, disclosure a positive amyloid-PET result might have psychological risks. Objective To assess outcomes in explore which variables associated safer positive. Design, Setting, Participants This prospective, multicenter study was conducted The Amyloid Imaging Prevent Disease Diagnostic Patient Management Study (AMYPAD-DPMS) (recruitment period: from April 2018 October 2020). setting 5 European memory clinics, participants included patients underwent amyloid-PET. Statistical analysis performed July 2022. Exposures Disclosure result. Main Outcomes Measures Psychological were defined (1) related distress, assessed using Impact Event Scale–Revised (IES-R; scores least 33 indicate probable presence posttraumatic stress disorder [PTSD]); (2) anxiety depression, Hospital Anxiety Depression scale (HADS; 15 severe mood symptoms). Results After disclosure, 27 (median [IQR] age, 70 [66-74] years; gender: 14 men [52%]; median education: [13 17] years, Mini-Mental State Examination [MMSE] score, 29 [28 30]) had (IQR) IES-R total score (10 [2 14] vs 0 [0 2]; P < .001), avoidance (0.00 [0.00 0.69] 0.00 0.00]; intrusions (0.50 [0.13 0.75] 0.25]; hyperarousal (0.33 0.67] .001) than 78 amyloid-negative [IQR], 67 [64 74] 45 [58%], [12 MMSE score: 30]). There no observed differences between HADS (–1.0 [–3.0 1.8] –2.0 [–4.8 1.0]; = .06) [–2.0 0.0] –1.0 0.0]; .46) deltas (score after – baseline). In SCD+, despite small sample size, education lower disclosure-related distress (ρ –0.43; .02) whereas partner ( W 7.5; .03). No showed PTSD or depression symptoms follow-up. Conclusions Relevance bigger change, yet such change did not reach threshold for concern.
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