Vaccine-Preventable Infections Among Solid Organ Transplant Recipients in Switzerland

• DOI: 10.1001/jamanetworkopen.2023.10687
• Publication Date: 2023-04-28T15:33:57Z
• Authors: Laura N. Walti; Catrina Mugglin; Matteo Mombelli; Oriol Manuel; Hans H. Hirsch; Nina Khanna; Nicolas J. Mueller; Christoph Berger; Katia Boggian; Christian Garzoni; Dionysios Neofytos; Christian van Delden; Mirjam Mäusezahl; Cédric Hirzel; ; Patrizia Amico; John-David Aubert; Vanessa Banz; Sonja Beckmann; Guido Beldi; Christoph Berger; Ekaterine Berishvili; Annalisa Berzigotti; Isabelle Binet; Pierre-Yves Bochud; Sandra Branca; Heiner Bucher; Emanuelle Catana; Anne Cairoli; Yves Chalandon; Sabina De Geest; Olivier De Rougemont; Sophie De Seigneuex; Michael Dickenmann; Joëlle Lynn Dreifuss; Michel Duchosal; Thomas Fehr; Sylvie Ferrari-La...; Christian Garzoni; Déla Golshayan; Nicolas Goossens; Fadi Haidar; Jörg Halter; Dominik Heim; Christoph Hess; Sven Hillinger; Hans H. Hirsch; Patricia Hirt; Günther Hofbauer; Uyen Huynh-Do; Franz Immer; Michael Koller; Mirjam Laager; Bettina Laesser; Frédéric Lamoth; Roger Lehmann; Alexander Leichtle; Oriol Manuel; Hans-Peter Marti; Michele Martinelli; Valérie McLin; Katell Mellac; Aurélia Mercay; Karin Mettler; Antonia Müller; Nicolas J. Müller; Ulrike Müller-Arndt; Beat Müllhaupt; Mirjam Nägeli; Graziano Oldani; Manuel Pascual; Jakob Passweg; Rosemarie Pazeller; Klara Posfay-Barbe; Juliane Rick; Anne Rosselet; Simona Rossi; Silvia Rothlin; Frank Ruschitzka; Thomas Schachtner; Urs Schranz; Stefan Schaub; Alexandra Scherrer; Aurelia Schnyder; Macé Schuurmans; Simon Schwab; Thierry Sengstag; Federico Simonetta; Susanne Stampf; Jürg Steiger; Guido Stirnimann; Ueli Stützinger; Christian Van Delden; Jean-Pierre Venetz; Jean Villard; Julien Vionnet; Madelaine Wick; Markus Wilhelm; Patrick Yerly
• Keywords: Solid organ

Vaccine responses are decreased in solid organ transplant (SOT) recipients, and given the complexity of implementation, vaccination programs may be suboptimal. The actual burden vaccine-preventable infections (VPIs) among SOT recipients remains unclear.To assess incidence rate VPIs to evaluate whether at increased risk for specific compared with general population.This nationwide cohort study used data from Swiss Transplant Cohort Study on individuals who underwent May 2008 June 2019 (follow-up until December 2019) Federal Office Public Health notifiable population same period. Data were analyzed January 2021 2022.Solid transplant.The main outcomes following recipients: hepatitis A B, diphtheria, Haemophilus influenzae infection, influenza, measles, mumps, pertussis, pneumococcal disease, poliomyelitis, meningococcal rubella, tetanus, tick-borne encephalitis, varicella zoster virus infection. Age-adjusted standardized ratios occurred more frequently population. For factors associated occurrence explored morbidity mortality assessed.Of 4967 enrolled (median age, 54 years [IQR, 42-62 years]; 3191 [64.2%] male), 593 (11.9%) experienced least 1 VPI. overall VPI was higher that (30.57 per 1000 person-years [PY]; 95% CI, 28.24-33.10 PY) (0.71 PY). age-adjusted ratio (27.84; 25.00-31.00). In influenza infection accounted most episodes (16.55 PY [95% 14.85-18.46 PY] 12.83 11.40-14.44 PY], respectively). total 198 575 (34.4%) led hospital admission, a an death and/or graft loss (hazard ratio, 2.44; 1.50-3.99; P = .002). multivariable analysis, age 65 or older time (incidence [IRR], 1.29; 1.02-1.62) receipt lung (IRR, 1.77; 1.38-2.26) heart 1.40; 1.05-1.88) occurrence.In this study, 11.9% VPIs, than There significant these SOT, which highlights need optimizing immunization strategies.