Association of NO2 and Other Air Pollution Exposures With the Risk of Parkinson Disease

• DOI: 10.1001/jamaneurol.2021.1335
• Publication Date: 2021-05-17T15:36:11Z
• Authors: Sungyang Jo; Ye-Jee Kim; Kye Won Park; Yun Su Hwang; Seung Hyun Lee; Bum Joon Kim; Sun Ju Chung
• Keywords: Adult; Male; Air Pollutants; Carbon Monoxide; Nitrogen Dioxide; Parkinson Disease; Middle Aged; 16. Peace & justice; 3. Good health; Cohort Studies; 03 medical and health sciences; Ozone; 0302 clinical medicine; 13. Climate action; Air Pollution; Republic of Korea; 11. Sustainability; Humans; Sulfur Dioxide; Female; Particulate Matter; Aged; Retrospective Studies

<h3>Importance</h3> The development of Parkinson disease (PD) may be promoted by exposure to air pollution. <h3>Objective</h3> To investigate the potential association between particulate matters (PM_2.5and PM₁₀), nitrogen dioxide (NO₂), ozone (O₃), sulfur (SO₂), and carbon monoxide (CO) risk incident PD. <h3>Design, Setting, Participants</h3> This retrospective cohort study used data from Korean National Health Insurance Service. Among 1 021 208 individuals in database, those who had lived Seoul January 2002 December 2006 (n = 176 875) were screened for eligibility. A total 78 830 adults older than 40 years without PD included this study. Individuals diagnosed with before 159) or younger 97 886) excluded. Each participant was followed up annually 2007 2015, thereby adding 757 704 person-years follow-up. Data analyzed September 2020. <h3>Exposures</h3> Individual levels PM_2.5, PM₁₀, NO₂, O₃, SO₂, CO estimated based on participants’ residential address at district level. evaluate long-term pollution, time-varying 5-year mean pollutant calculated each participant. <h3>Main Outcomes Measures</h3> outcome measure pollution measured as hazard ratios after adjusting demographic factors, socioeconomic medical comorbidities. <h3>Results</h3> At baseline, (SD) age participants 54.4 (10.7) years, 41 070 (52.1%) female. 338 newly identified during period. Exposure NO₂was associated an increase (hazard ratio highest vs lowest quartile, 1.41; 95% CI, 1.02-1.95;<i>P</i>for trend .045). No statistically significant associations PM_2.5,PM₁₀, incidence found. <h3>Conclusions Relevance</h3> In large study, a NO₂exposure identified. finding suggests role pollutants development, advocating need implement targeted public health policy.