Prevalence, Timing, and Network Localization of Emergent Visual Creativity in Frontotemporal Dementia

• DOI: 10.1001/jamaneurol.2023.0001
• Publication Date: 2023-02-27T16:01:03Z
• Authors: Adit Friedberg; Lorenzo Pasquini; Ryan Diggs; Erika A. Glaubitz; Lucia Lopez; Ignacio Illán-Gala; Leonardo Iaccarino; Renaud La Joie; Nidhi Mundada; Marguerite Knudtson; Kyra Neylan; Jesse Brown; Isabel Elaine Allen; Katherine P. Rankin; Luke W. Bonham; Jennifer S. Yokoyama; Eliana M. Ramos; Daniel H. Geschwind; Salvatore Spina; Lea T. Grinberg; Zachary A. Miller; Joel H. Kramer; Howard Rosen; Maria Luisa Gorno...; Gil Rabinovici; William W. Seeley; Bruce L. Miller
• Keywords: Semantic dementia; Frontotemporal lobar degeneration; Temporal cortex; Frontal lobe; Occipital lobe

The neurological substrates of visual artistic creativity (VAC) are unknown. VAC is demonstrated here to occur early in frontotemporal dementia (FTD), and multimodal neuroimaging used generate a novel mechanistic hypothesis involving dorsomedial occipital cortex enhancement. These findings may illuminate mechanism underlying human creativity.