The Impact of Systemic Lupus Erythematosus on the Clinical Phenotype of Antiphospholipid Antibody–Positive Patients: Results From the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Clinical Database and Repository

• DOI: 10.1002/acr.23584
• Publication Date: 2018-04-18T21:06:11Z
• Authors: Ozan Unlu; Doruk Erkan; Medha Barbhaiya; Danieli Andrade; Iana Nascimento; Renata Rosa; Alessandra Banzato; Vittorio Pengo; Amaia Ugarte; Maria Gerosa; Lanlan Ji; Maria Efthymiou; D. Ware Branch; Guilherme Ramires...; Angela Tincani; H. Michael Belmont; Paul R. Fortin; Michelle Petri; Esther Rodriguez; Guillermo J. Pons...; Jason S. Knight; Tatsuya Atsumi; Rohan Willis; Stephane Zuily; Maria G. Tektonidou
• Keywords: Adult; Male; Internationality; Databases, Factual; Middle Aged; Antiphospholipid Syndrome; 3. Good health; 03 medical and health sciences; Phenotype; 0302 clinical medicine; Rheumatology; Geriatrics; Pregnancy; Health Sciences; Antibodies, Antiphospholipid; Humans; Lupus Erythematosus, Systemic; Female; Registries

Objective Although systemic lupus erythematosus ( SLE ) is the most common autoimmune disease associated with antiphospholipid antibodies aPL ), limited data exist regarding impact of on clinical phenotype ‐positive patients. The primary objective this study was to compare clinical, laboratory, and treatment characteristics patients those without SLE. Methods A secure web‐based capture system used store patient demographic ‐related laboratory characteristics. Inclusion criteria included positive according updated Sapporo classification criteria. Antiphospholipid antibody–positive fulfilling American College Rheumatology for (“ ”) no other diseases only”) were in analysis. Results Six hundred seventy‐two recruited from 24 international centers; 426 these did not have disease, 197 had . frequency thrombocytopenia, hemolytic anemia, low complement levels, IgA anti–β 2 ‐glycoprotein I (anti‐β GPI higher , whereas cognitive dysfunction IgG anti‐β ‐only group. arterial venous thromboses (including recurrent) as well pregnancy morbidity similar groups. prevalence cardiovascular risk factors at time entry into registry differ between groups, exception current smoking, which more frequent Conclusion frequencies thrombosis are diagnosis persistently an increased antibodies.