Robust control of depth of anesthesia

• DOI: 10.1002/acs.1087
• Publication Date: 2008-11-04T09:54:24Z
• Authors: Guy A. Dumont; Arturo Martinez; J. Mark Ansermino
• Keywords: Set point; Divergence (linguistics)

Abstract This paper presents a systematic procedure to design both robust PID controllers and based on fractional calculus (based Commande Robuste d'Ordre Non Entier, or CRONE methodology) regulate the hypnotic state of anesthesia with intravenous administration propofol. The objective is provide an adequate drug regimen for propofol avoid under over dosing patients. are designed compensate patients inherent drug–response variability (uncertainty), achieve good output disturbance rejection, attain set point response. performance assessed by calculating typical time domain measures using median PE, absolute divergence, wobble. Copyright © 2008 John Wiley & Sons, Ltd.