The Relationship between Dietary Macronutrient Composition and Telomere Length Among US Adults

• DOI: 10.1002/adbi.202300619
• Publication Date: 2024-01-17T04:24:53Z
• Authors: Nicholas A. Koemel; Nasser Laouali; Alistair M. Senior; David S. Celermajer; Amanda Grech; Samantha M. Solon...; Stephen J. Simpson; David Raubenheimer; Timothy P. Gill; Michael R. Skilton
• Keywords: Adult; Male; 0303 health sciences; 03 medical and health sciences; Cross-Sectional Studies; Humans; Female; Nutrients; Telomere; Nutrition Surveys; Diet

Abstract The role of dietary macronutrients and energy intake in the aging process has been well‐established. However, previous research mainly focused on association between leukocyte telomere length (LTL) individual macronutrients, while effects macronutrient composition LTL remain unclear. This cross‐sectional analysis involved 4130 US adults (44.8 ± 17.0 years; 51% female) from National Health Nutrition Examination Survey during 1999–2002. A single 24‐h recall is used to collect data. relationship examined using three‐dimensional generalized additive models. After adjustment for age, sex, ethnicity, education, physical activity, BMI, quality, a with (P = 0.02) revealed. Diets lower protein (5–10%), higher carbohydrates (75%), fat (15–20%) are associated longest corresponding 7.7 years slower biological aging. lowest (5%) carbohydrate (40%), highest (55%) shortest LTL, accelerated 4.4 years. associations appeared magnified intake. These findings support complex independent diet quality.