Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration.

• DOI: 10.1002/adbi.202400800
• Publication Date: 2025-04-17
• Authors: Yuzheng Lu; Y. Shan; Yingjie Xiong; Jianting Ye; Yanbin Wu; Jipeng Song; Yao Zhang; Wancheng Lin; Haoye Meng; Wenjing Xu; Peng Jiang; Qiang Lü; Lixiang Ding
• Keywords: Bioactive Glass; Magnesium phosphate; Calcium phosphate cement

Magnesium phosphate cement (MPC) continues to gain attention in the field of biomedicine. However, its suboptimal mechanical strength and weak biological activity hinder wider clinical application. Given excellent characteristics bioglass fiber (BGF), In this study, magnesium bone (BMPC) containing MPC BGF with different concentrations (0%, 10%, 20%) are fabricated. Called (MPC, 10BMPC, 20BMPC) respectively. BGF-induced strengthening is verified through physical chemical performance tests. vitro experiments showed that BMPC have better osteogenic properties than can enhance proliferation adhesion capacity human umbilical vein endothelial cells. vivo experiment, 20BMPC significantly promote regeneration vascular network formation, histological analysis further confirmed 20BMPC. Transcriptomic analyses activities Notch pathway Hif1 upregulated group, reflecting strong interconnection between osteogenesis angiogenesis. 20BMPC, which highest content, best among all tested materials. This study improved enhanced angiogenic abilities. Therefore, be used as a new repair material.