Templated Assembly of pH‐Labile Polymer‐Drug Particles for Intracellular Drug Delivery

• DOI: 10.1002/adfm.201201191
• Publication Date: 2012-07-12T07:56:01Z
• Authors: Jiwei Cui; Yan Yan; Yajun Wang; Frank Caruso
• Keywords: Conjugate

Abstract The preparation of pH‐labile polymer‐drug particles via mesoporous silica‐templated assembly for anticancer drug delivery into cancer cells is reported. conjugate synthesized thiol‐maleimide click chemistry using thiolated poly(methacrylic acid) (PMA SH ) and a doxorubicin (Dox) derivative. Drug‐loaded polymer that are stable under physiological conditions obtained through infiltration the conjugates silica particles, followed by cross‐linking PMA chains, subsequent removal porous templates. encapsulated Dox released from cleavage hydrazone bonds between at endosomal/lysosomal pH. Cell viability assays show assembled have negligible cytotoxicity to LIM1899 human colorectal cells. In comparison, Dox‐loaded cause significant cell death following internalization. reported represent novel versatile class stimuli‐responsive carriers controlled delivery.