Antibiotic‐Releasing Silk Biomaterials for Infection Prevention and Treatment

• DOI: 10.1002/adfm.201201636
• Publication Date: 2012-09-26T16:58:31Z
• Authors: Eleanor M. Pritchard; Thomas Valentin; Bruce Panilaitis; Fiorenzo Omenetto; David L. Kaplan
• Keywords: Biocompatibility; Biomaterial

Abstract Effective treatment of infections in avascular and necrotic tissues can be challenging due to limited penetration into the target tissue systemic toxicities. Controlled‐release polymer implants have potential achieve high local concentrations needed while also minimizing exposure. Silk biomaterials possess unique characteristics for antibiotic delivery, including biocompatibility, tunable biodegradation, stabilizing effects, water‐based processing, diverse material formats. The functional release antibiotics spanning a range chemical properties from different formats silk (films, microspheres, hydrogels, coatings) is reported. penicillin ampicillin bulk‐loaded films, drug‐loaded microspheres suspended hydrogels investigated vivo efficacy ampicillin‐releasing demonstrated murine infected‐wound model. sponges with nanofilm coatings are loaded gentamicin cefazolin, sustained 5 3 days, respectively. capability carriers sequester, stabilize, then bioactive represents major advantage over pumps based on liquid drug reservoirs, where instability at room or body temperature limiting. present studies demonstrate that represent novel, customizable platform focal delivery using (injectable implantable).