A Low‐Toxic Multifunctional Nanoplatform Based on Cu9S5@mSiO2 Core‐Shell Nanocomposites: Combining Photothermal‐ and Chemotherapies with Infrared Thermal Imaging for Cancer Treatment

• DOI: 10.1002/adfm.201203317
• Publication Date: 2013-04-09T08:26:40Z
• Authors: Guosheng Song; Qian Wang; Yang Wang; Gang Lv; Chun Li; Rujia Zou; Zhigang Chen; Zongyi Qin; Keke Huo; Ronggui Hu; Junqing Hu
• Keywords: Biocompatibility; Nanomaterials

Abstract Copper chalcogenides have been demonstrated to be a promising photothermal agent due their high conversion efficiency, synthetic simplicity, and low cost. However, the hydrophobic less biocompatible characteristics associated with processes hamper widely biological applications. An alternative strategy for improving hydrophilicity biocompatibility is coat copper chalcogenide nanomaterials silica shell. Herein, rational preparation design results in successful coating mesoporous (mSiO 2 ) on as‐synthesized Cu 9 S 5 nanocrystals, forming @mSiO ‐PEG core‐shell nanostructures. As‐prepared nanostructures show cytotoxicity excellent blood compatibility, are effectively employed ablation of cancer cells infrared thermal imaging. Moreover, anticancer drug doxorubicin (DOX)‐loaded pH sensitive release profile therefore beneficial delivery DOX into chemotherapy. Importantly, combination photothermal‐ chemotherapies demonstrates better effects therapy treatment than individual approaches vitro vivo.