A Cooperative Copper Metal–Organic Framework‐Hydrogel System Improves Wound Healing in Diabetes

• DOI: 10.1002/adfm.201604872
• Publication Date: 2016-11-23T07:35:28Z
• Authors: Jisheng Xiao; Siyu Chen; Ji Yi; Hao F. Zhang; Guillermo A. Ameer
• Keywords: Chronic wound

Chronic non-healing wounds remain a major clinical challenge that would benefit from the development of advanced, regenerative dressings promote wound closure within clinically relevant time frame. The use copper ions has shown promise in healing applications possibly by promoting angiogenesis. However, reported treatments require multiple salts or oxides to bed, exposing patient potentially toxic levels and resulting variable outcomes. Herein we set out assess whether metal organic framework nanoparticles (HKUST-1 NPs) embedded an antioxidant thermoresponsive citrate-based hydrogel decrease ion toxicity accelerate diabetic mice. HKUST-1 poly-(polyethyleneglycol citrate-co-N-isopropylacrylamide) (PPCN) were synthesized characterized. NP stability protein solution with without embedding them PPCN was determined. Copper release, cytotoxicity, apoptosis, vitro migration processes measured. Wound rates blood perfusion assessed vivo using splinted excisional dermal mouse model. disintegrated while NPs (H-HKUST-1) protected degradation slowly released. Cytotoxicity apoptosis due release significantly reduced cell enhanced. In vivo, H-HKUST-1 induced angiogenesis, collagen deposition, re-epithelialization during These results suggest cooperatively stabilized, ion-releasing is promising innovative dressing for treatment chronic wounds.