Ultrasmall CuCo2S4 Nanocrystals: All‐in‐One Theragnosis Nanoplatform with Magnetic Resonance/Near‐Infrared Imaging for Efficiently Photothermal Therapy of Tumors

• DOI: 10.1002/adfm.201606218
• Publication Date: 2017-01-23T13:24:23Z
• Authors: Bo Li; Fukang Yuan; Guanjie He; Xiaoyu Han; Xin Wang; Jinbao Qin; Zheng Xiao Guo; Xinwu Lu; Qian Wang; Ivan P. Parkin; Chengtie Wu
• Keywords: Technology; photothermal therapy; Materials Science; Cancer-Cells; Condensed Matter; Special Points; 02 engineering and technology; DFT calculations; 01 natural sciences; Agent; Quantum Dots; Physical; Nanoscience & Nanotechnology; Science & Technology; Multidisciplinary; Conversion Efficiency; Research; Physics; 540; 543; Fe5C2 Nanoparticles; Renal Clearance; 3. Good health; 0104 chemical sciences; Chemistry; CuCo2S4 nanocrystals; Brillouin-Zone; 13. Climate action; Legacy; Physical Sciences; Applied; Facile Synthesis; Science & Technology - Other Topics; 0210 nano-technology; ternary bimetal chalcogenides; ultrasmall magnetic resonance imaging; 980 nm laser

Copper‐based ternary bimetal chalcogenides have very promising potential as multifunctional theragnosis nanoplatform for photothermal treatment of tumors. However, the design and synthesis of such an effective platform remains challenging. In this study, hydrophilic CuCo2S4 nanocrystals (NCs) with a desirable size of ≈10 nm are synthesized by a simple one‐pot hydrothermal route. The as‐prepared ultrasmall CuCo2S4 NCs show: 1) intense near‐infrared absorption, which is attributed to 3d electronic transitions from the valence band to an intermediate band, as identified by density functional theory calculations; 2) high photothermal performance with a photothermal conversion efficiency up to 73.4%; and 3) capability for magnetic resonance (MR) imaging, as a result of the unpaired 3d electrons of cobalt. Finally, it is demonstrated that the CuCo2S4 NCs are a promising “all‐in‐one” photothermal theragnosis nanoplatform for photothermal cancer therapy under the irradiation of a 915 nm laser at a safe power density of 0.5 W cm−2, guided by MR and infrared thermal imaging. This work further promotes the potential applications of ternary bimetal chalcogenides for photothermal theragnosis therapy.