Rational Design of Multifunctional CuS Nanoparticle‐PEG Composite Soft Hydrogel‐Coated 3D Hard Polycaprolactone Scaffolds for Efficient Bone Regeneration

• DOI: 10.1002/adfm.202202470
• Publication Date: 2022-06-03T21:14:51Z
• Authors: Xu Xue; Hao Zhang; Han Liu; Sicheng Wang; Jiadong Li; Qirong Zhou; Xiao Chen; Xiaoxiang Ren; Yingying Jing; Yonghui Deng; Zhen Geng; Xiuhui Wang; Jiacan Su
• Keywords: Polycaprolactone

Abstract 3D‐printed polycaprolactone (PCL) scaffolds have been extensively studied for application in bone tissue engineering. However, PCL‐based with enhanced bioactivity and intelligent delivery capability repair remains challenging. Herein, CuS nanoparticle‐PEG soft hydrogel‐coated 3D hard (denoted as CuS‐PEG‐PCL scaffold) are rationally designed efficient regeneration. nanoparticles cross‐linked PEG hydrogel (CuS‐PEG‐hydrogel) endows the scaffold excellent photothermal properties stable elasticity, while PCL provides mechanical performance. Upon exposure to 1064 nm near‐infrared (NIR) light irradiation, dexamethasone sodium phosphate (Dexp), stored scaffold, can be controllably released, which efficiently promotes osteogenic differentiation of mesenchymal stem cells (BMSCs). In addition, combination mild heating at 42 ± 0.5 °C further promoted BMSCs. Subsequently, this Dexp‐loaded (D‐CuS‐PEG‐PCL NIR treatment tibial defect rats presented highest regeneration capacity. These findings demonstrate that CuS‐PEG‐hydrogel effectively modify printed scaffold. Therefore, multifunctional a soft‐hard hybrid structure has potential become an advanced drug vehicle large defects.