Hybrid Shear‐Thinning Hydrogel Integrating Hyaluronic Acid with ROS‐Responsive Nanoparticles

• DOI: 10.1002/adfm.202213368
• Publication Date: 2023-05-02T04:18:44Z
• Authors: Mariah G. Bezold; Andrew R. Hanna; Bryan R. Dollinger; Prarthana Patil; Fang Yu; Craig L. Duvall; Mukesh K. Gupta
• Keywords: Adamantane

Abstract Nanoparticle (NP) supra‐assembly offers unique opportunities to tune macroscopic hydrogels’ mechanical strength, material degradation, and drug delivery properties. Here, synthetic, reactive oxygen species (ROS)‐responsive NPs are physically cross‐linked with hyaluronic acid (HA) through guest‐host chemistry create shear‐thinning NP/HA hydrogels. A library of triblock copolymers composed poly(propylene sulfide)‐ b ‐poly(N, N ‐dimethylacrylamide)‐ ‐dimethylacrylamide‐ co ‐N‐(1‐adamantyl)acrylamide) synthesized varied architectures adamantane grafting densities then self‐assembled into displaying on their surface. Self‐assembled mixed β‐cyclodextrin grafted HA yield eighteen hydrogel formulations. The platform demonstrates superior strength HA‐only hydrogels, susceptibility oxidative/enzymatic inherent cell‐protective, antioxidant function. performance hydrogels is shown be affected by architecture, guest/host densities, composition. In particular, the length hydrophilic second block density significantly impacts properties behavior, while ROS‐reactivity sulfide) protects cells from cytotoxic ROS reduces oxidative degradation compared This study provides insight polymer structure‐function considerations for designing hybrid identifies antioxidant, as promising injectable platforms small molecule drugs therapeutic cells.