Pathology‐Guided Cell Membrane‐Coated Polydopamine Nanoparticles for Efficient Multisynergistic Treatment of Periodontitis

• DOI: 10.1002/adfm.202312253
• Publication Date: 2024-02-15T10:15:48Z
• Authors: Shengyuan Pan; Wenjie Zhong; Yuyan Lan; Simin Yu; Lanxin Yang; Fengze Yang; Jinda Li; Xiang Gao; Jinlin Song
• Keywords: Biocompatibility; Biointerface; Periodontal fiber

Abstract Nanodrug delivery systems (NDDSs) for the treatment of periodontitis remain a significant clinical challenge. The low biocompatibility, singular effect, and lack disease specificity conventional nanoparticles limit their biomedical application. Recent studies have highlighted pivotal role cell membrane‐coated nanotechnology in anti‐inflammatory strategies due to its improved biocompatibility superior biointerface properties. Herein, combined with pathological heterogeneity revealed by bioinformatics analysis, this study develops novel nanoparticle composed two elements: minocycline‐loaded polydopamine (PM) cRGD‐modified membrane (RCM). vitro results indicate that PM@RCM rescues impaired human periodontal ligament stem cells through antioxidant, anti‐ferroptosis, anti‐inflammatory, pro‐osteogenic effects, exhibits favorable antibacterial bioactivity. vivo further reveal promotes tissue regeneration remodeled homeostasis mice. Collectively, these findings highlight unique changes periodontitis. Moreover, NDDS developed study, which leverages excellent natural properties versatility cores, provides promising strategy