A Self‐Powered Wound Dressing Based on “Lock‐ON/OFF” Drug Release Combined Electric Stimulus Therapy for Accelerated Infected Wound Healing

• DOI: 10.1002/adfm.202315086
• Publication Date: 2024-02-10T10:41:31Z
• Authors: Yani Sun; Yufei Tang; Yuxuan He; Lei Chen; Cong Wu; Bo Zhang; Fuxue Yan; Kang Zhao; Zixiang Wu
• Keywords: 0301 basic medicine; 0303 health sciences

Abstract To facilitate the on‐demand release of hydrophilic antibiotics for accelerated repair infected wounds, a self‐powered wound dressing incorporating “Lock‐ON/OFF” electric field (EF)‐driven drug mechanism combined with electrical stimulation (ES) therapy is presented. When subjected to mechanical stress, exhibits controlled, slow‐release behavior, achieving remarkable cumulative rate 88.57%—89 times higher than non‐mechanical stress group. Conversely, in absence remains unreleased, maintaining 0% fully closed state. The utilizes its piezoelectric effect establish an field, enabling precise control by regulating electrostatic balance between carrier and drug. Moreover, acts as exogenous remodeling endogenous wound, accelerating closure. Combining EF‐driven ES result 1.26 fold improvement healing compared alone. This study addresses precision limitations automated diagnosis treatment, paving way advancements remote diagnosis, wireless therapy, medicine.