Neutrophil Hitchhiking Biomimetic Nanozymes Prime Neuroprotective Effects of Ischemic Stroke in a Tailored “Burning the Bridges” Manner

• DOI: 10.1002/adfm.202315275
• Publication Date: 2024-03-10T20:15:05Z
• Authors: Junyan Song; Guang Yang; Yan Song; Zeyu Jiang; Yue Jiang; Yuxia Luan; Wenxiu He
• Keywords: Stroke

Abstract Reperfusion injury of ischemic stroke, characterized by the uncontrolled production reactive oxygen species (ROS) and inflammatory reactions, continues to present a major problem in clinical treatment. Neutrophils are forerunners infiltrate cerebral regions contribute reperfusion injury. Herein, this study reports tailored “burning bridges” strategy designing biomimetic nanozymes (D@HPB@SPM NPs) diminish stroke. D@HPB@SPM NPs composed sialic acid (SA)‐modified platelet membrane shell hollow Prussian blue nanoparticle core loaded with Deoxyribonuclease I (DNase I). Due unique binding affinity SA L‐selectin, which is abundantly expressed circulating neutrophils, can effectively hitchhike on neutrophils across blood‐brain barrier into injured brain parenchyma after intravenous injection. Following this, activated unleash through producing neutrophil extracellular traps (NETs). not only relieve oxidative stress efficiently scavenging ROS, but also mitigate neutrophil‐induced degrading NETs manner similar bridges”. The encouraging accumulation their efficient therapeutic efficacy systematically validated stroke rats. This work offers fresh insight for