Interventional Hydrogel Microsphere Controlled‐Releasing Curcumin for Photothermal Therapy against Endometriosis

• DOI: 10.1002/adfm.202315907
• Publication Date: 2024-02-24T04:01:30Z
• Authors: Xuemin Liu; Shengtao Yan; Hongliang Wu; Ming Chen; Hao Dai; Zhenxing Wang; Muyuan Chai; Qingyu Hu; Dongdong Li; Lei Chen; Ruiying Diao; Shi Chen; Liping Wang; Xuetao Shi
• Keywords: Biocompatibility

Abstract Endometriosis is a prevalent gynecological disorder characterized by the presence of endometrial‐like tissue outside uterus, causing chronic pelvic pain, painful periods, and infertility. Despite common use hormone therapy surgical lesion excision in its treatment, there remain significant postoperative risks potential side effects, with high recurrence rate. An efficient nonsurgical treatment for this condition therefore urgently needed. In study, an interventional hydrogel microsphere near‐infrared (NIR)‐controlled curcumin release developed non‐invasive thermal endometriosis. The microspheres demonstrate good biocompatibility photothermal activities, death endometrial stromal cells under NIR controlled (Cur) release. When injected into endometriotic lesions stimulated light, (Cur‐FeHMPs) can raise temperature to 43.65 °C, inducing elimination. Furthermore, from inhibits proinflammatory environment Cur‐FeHMPs combination present novel strategy endometriosis treatment.