Engineered PVDF/PLCL/PEDOT Dual Electroactive Nerve Conduit to Mediate Peripheral Nerve Regeneration by Modulating the Immune Microenvironment

• DOI: 10.1002/adfm.202400217
• Publication Date: 2024-03-05T12:54:30Z
• Authors: Qiqi Wang; Yingqi Wei; Xiaohong Yin; Guancheng Zhan; Xiaodong Cao; Huichang Gao
• Keywords: Electrical conduit; Nerve guidance conduit; Peripheral nerve injury

Abstract Electroactive materials are increasingly recognized for their efficacy in promoting the repair of peripheral nerve injury. However, mechanism by which electroactive promote regeneration modulating immune microenvironment remains incompletely explored. In this study, a PVDF/PLCL/PEDOT artificial conduit with dual electroactivity integrating piezoelectric properties and electrical conductivity is constructed. The exhibited excellent spontaneous conductive properties, superior suture resistance anti‐twisting properties. Detailed vitro cell experiments vivo animal conducted, revealing that can effectively rat sciatic while facilitating reconstruction both conduction function motor function. Furthermore, underlying depth investigated found material regulate activating PI3K/AKT‐Nrf2 signaling pathway, thereby macrophage polarization toward M2 anti‐inflammatory phenotype. This subsequently facilitated Schwann recruitment myelin formation through mediation paracrine system. Importantly, blocking pathways diminished effectiveness repair. work elucidated how modulate to positively impact repair, highlighting critical role modulation