Mesoporous‐Confined Au Thorn Nano‐Pockets Enable of Precisely Capturing Target Molecules for Universal SERS Detection

• DOI: 10.1002/adfm.202419885
• Publication Date: 2025-02-11T06:37:16Z
• Authors: Pingyong Liao; Jing Zhao; Xuejun Zhao; Xiru Wang; Lu Xiao; Ruijia Chen; Zihua Zhang; Junchang Wang; Shan He; Wenbin Liu

Abstract A persistent challenge in utilizing gold nanostructures for surface‐enhanced Raman scattering (SERS) lies positioning analytes into the nanoscale hotspots that maximize SERS performance and achieve universal substrates. Here, a novel mesoporous nano‐pockets strategy is proposed to design high substrates by precisely capturing target molecules plasmonic hotspots. This achieved through silica as confined growth of short Au thorns on Fe 3 O 4 core (Fe @sAT@mSiO 2 ), whilst vertically open structure with nanospace large enough at tips capture hydroxyl group surface. The electromagnetic field enhancement obtained from an average gap size nm sufficient amplify signal peaks trapped molecules. Therefore, as‐prepared proves be ultrasensitive reliable detection 15 kinds drugs, all limits lower than those reported current literature. Moreover, experimental findings are further corroborated simulations using molecular dynamics finite element method. These mesoporous‐confined thorn accessible promote future use developing method various fields.