A Dual‐Catalysis Mode for ROS Regulation to Accelerate Biointegration of Implants in Infected Diabetic Wound

• DOI: 10.1002/adfm.202423015
• Publication Date: 2025-03-24T14:41:50Z
• Authors: Huihui Xie; Lan Zhang; Jun Chen; Chen Wang; Yaxi Yan; Shulai Deng; Kang Liu; Dongsheng Li; Mo Yang; Jiachen Ren; Shuilin Wu; Yong Han

AbstractPathological microenvironment of diabetes including hyperglycemia, excessive reactive oxygen species (ROS), and accumulation of advanced glycation end products leads to high risk of infection and persistent inflammatory reaction, retarding biointegration of implants. To address this issue, a dual‐catalysis system consisting of Na2TiO3 nanotubes with CeO2 nanodots and polydopamine (PDA) cover is constructed on Ti implant to manipulate ROS generation and scavenging for antibiosis and tissue regeneration. Na2TiO3 and CeO2 form heterojunction, in which oxygen vacancies (VOs) contribute to the separation of electron‐hole pairs under near‐infrared light (NIR) irradiation. In NIR mode, the photocatalysis‐induced ROS and photothermal‐induced hyperthermia by Na2TiO3‐CeO2 heterojunction and PDA cover synergistically kill bacteria efficiently. In non‐NIR mode, CeO2 nanodots and PDA cover show excellent superoxide dismutase (SOD) and catalases (CAT) like enzyme activities, and they catalyze ROS (e.g., ·O2 − and H2O2) thoroughly into benign O2 and H2O, relieving the oxidative stress of microenvironment and accelerating M2 macrophage phenotype. It helps biofunctional recovery of endothelial cells and fibroblasts, promoting tissue regeneration around implants in diabetic models. This work proposes a promising approach of manipulating ROS generation and scavenging to treat infection and regulate inflammatory reaction, thereby improving biointegration and performance of implants in diabetic microenvironment.