Mechanically Robust, Negative‐Swelling, Mussel‐Inspired Tissue Adhesives

• DOI: 10.1002/adhm.201200316
• Publication Date: 2012-11-23T15:16:17Z
• Authors: Devin G. Barrett; Grace G. Bushnell; Phillip B. Messer...
• Keywords: Propylene oxide

Abstract Most synthetic polymer hydrogel tissue adhesives and sealants swell considerably in physiologic conditions, which can result mechanical weakening adverse medical complications. This paper describes the synthesis characterization of mechanically tough zero‐ or negative‐swelling mussel‐inspired surgical based on catechol‐modified amphiphilic poly(propylene oxide)‐poly(ethylene oxide) block copolymers. The formation, swelling, bulk mechanical, adhesive properties resulting thermosensitive gels were characterized. Catechol oxidation at below room temperature rapidly resulted a chemically cross‐linked network, with subsequent warming to physiological inducing thermal hydrophobic transition PPO domains providing mechanism for volumetric reduction toughening. described approach be easily adapted other thermally sensitive copolymers cross‐linking strategies, representing general that employed control swelling enhance hydrogels used context.