New Insights Into Alzheimer's Disease Amyloid Inhibition: Nanosized Metallo‐Supramolecular Complexes Suppress Aβ‐Induced Biosynthesis of Heme and Iron Uptake in PC12 Cells

• DOI: 10.1002/adhm.201300470
• Publication Date: 2013-10-29T07:22:37Z
• Authors: Meng Li; Chuanqi Zhao; Taicheng Duan; Jinsong Ren; Xiaogang Qu
• Keywords: Neurotoxicity; Amyloid (mycology)

Nanosized metallo-supramolecular compounds, [Ni2 L3 ](4+) and [Fe2 , can not only strongly inhibit Aβ aggregation but also reduce the peroxidase activity of Aβ-heme. Further studies demonstrate that through blocking heme-binding site, these two compounds suppress Aβ-induced biosynthesis heme iron uptake in PC12 cells. This work provides new insights into molecular mechanisms inhibitors on Aβ-mediated neurotoxicity.