Brain Endothelial Cell Targeting Via a Peptide‐Functionalized Liposomal Carrier for Xenon Hyper‐CEST MRI

• DOI: 10.1002/adhm.201400224
• Publication Date: 2014-07-02T01:18:25Z
• Authors: Matthias Schnurr; Karl Sydow; Honor May Rose; Margitta Dathe; Leif Schröder
• Keywords: Radiography; Blood-Brain Barrier; Liposomes; Endothelial Cells; Humans; Peptides; 01 natural sciences; Cells, Cultured; Magnetic Resonance Angiography; 0104 chemical sciences

A nanoparticulate carrier system is used to efficiently deliver a contrast agent for highly sensitive xenon Hyper-CEST MRI. The carrier system not only improves the biocompatibility and solubility of the contrast agent, it also allows selective cell targeting as demonstrated by the discrimination of human brain capillary and aortic endothelial cells.