In Vitro and In Vivo Evaluation of Whitlockite Biocompatibility: Comparative Study with Hydroxyapatite and β‐Tricalcium Phosphate

• DOI: 10.1002/adhm.201400824
• Publication Date: 2015-05-12T07:09:43Z
• Authors: Hae Lin Jang; Guang Bin Zheng; Jungha Park; Hwan D. Kim; Hae‐Ri Baek; Hye Kyoung Lee; Keunho Lee; Heung Nam Han; Choon‐Ki Lee; Nathaniel S. Hwang; Jae Hyup Lee; Ki Tae Nam
• Keywords: Whitlockite; Biomaterial; Biocompatibility; Bioceramic; Bone tissue; Human bone

Biomimicking ceramics have been developed to induce efficient recovery of damaged hard tissues. Among them, calcium phosphate‐based bioceramics the most widely used because their similar composition with human tissue and excellent biocompatibilities. However, incomplete understanding entire inorganic phases in natural bone has limited recreation complete compositions. In this work, broad biomedical evaluation whitlockite (WH: Ca 18 Mg 2 (HPO 4 ) (PO 12 ), which is secondary phase bone, conducted better understand seek potential application as a biomaterial. Based on recently gram‐scale method for synthesizing WH nanoparticles, properties material cellular scaffolding implants are assessed compared those hydroxyapatite (HAP: 10 6 (OH) β‐tricalcium phosphate (β‐TCP: β‐Ca 3 ). WH‐reinforced composite scaffolds facilitate bone‐specific differentiation HAP‐reinforced scaffolds. Additionally, or regeneration calvarial defects rat model HAP β‐TCP implants, intermediate resorbability. New findings that distinguish it from significant tissue, mimicking at nanoscale designing functional bioceramics.