Multifunctional Theranostic Nanoplatform for Cancer Combined Therapy Based on Gold Nanorods

• DOI: 10.1002/adhm.201500453
• Publication Date: 2015-09-02T17:58:57Z
• Authors: Wei‐Hai Chen; Cai‐Xia Yang; Wen‐Xiu Qiu; Guo‐Feng Luo; Hui‐Zhen Jia; Qi Lei; Xiao‐Yong Wang; Gang Liu; Ren‐Xi Zhuo; Xian‐Zheng Zhang
• Keywords: Nanorod; Cancer Therapy; Cancer Imaging

Nanomaterials that integrate diagnostic and therapeutic functions within a single nanoplatform promise great advances in revolutionizing cancer therapy. A smart multifunctional theranostic drug‐delivery system (DDS) based on gold nanorods (abbreviated as GNR/TSDOX) is designed for cancer‐targeted imaging imaging‐guided In this intelligent DDS, the active targeting ligand biotin introduced to track sites vivo. With aid of photothermal/photoacoustic imaging, GNR/TSDOX can ablate specifically effectively. When stimulated with near‐infrared (NIR) light source, NIR energy effectively absorbed converted into heat by localized photothermal therapy increase temperature also further triggers cascaded release anticancer drug combined thermo‐chemotherapy. More importantly, vivo cure effect be well guided regulating irradiation time intensity light.