Periodic Nanoneedle and Buffer Zones Constructed on a Titanium Surface Promote Osteogenic Differentiation and Bone Calcification In Vivo

• DOI: 10.1002/adhm.201500461
• Publication Date: 2015-12-03T08:34:49Z
• Authors: Peng Yu; Xiaojing Zhu; Xiaolan Wang; Shuangying Wang; Weiping Li; Guoxin Tan; Yu Zhang; Chengyun Ning
• Keywords: Nanoneedle

Rapid and effective bone mineralization at the bone/implant interface is required for successful orthopedic dental implants. In this study, two periodic microscale functionalized zones on titanium (MZT) are created, namely, nanoneedle buffer zones. The aim of design to provide spatially regulated topographical cues enhance efficacy regeneration. This goal achieved using a versatile technique in which structures hydrothermally constructed surface sheets, after selective laser irradiation used construct zonal MZT overcome suppressive effect film osteoblasts. Additionally, exhibits zone‐selective apatite deposition protein adsorption. accelerated vitro osteoblast differentiation nodule confirmed. Elemental analysis nodules formed by osteoblasts growing demonstrates they have different compositions. Histological scanning electron microscope formation vivo implants shows that process also enhanced implant. concept constructing implant could facilitate future research improving surfaces.