Mesoporous Silica Particles as a Multifunctional Delivery System for Pain Relief in Experimental Neuropathy

• DOI: 10.1002/adhm.201500996
• Publication Date: 2016-03-31T20:13:19Z
• Authors: Junran Xie; Dongju Xiao; Jinning Zhao; Nianqiang Hu; Qi Bao; Li Jiang; Lina Yu
• Keywords: Inflammation; Male; Analgesics; Drug Carriers; 0303 health sciences; Anti-Inflammatory Agents; Silicon Dioxide; Cell Line; 3. Good health; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Drug Delivery Systems; Hyperalgesia; Animals; Nanoparticles; Neuralgia; Pain Management; Dronabinol; Microglia; Oligopeptides; Oxidation-Reduction

The long‐term use of potent analgesics is often needed to treat chronic pain. However, it has been greatly hindered by their side effects such as addiction and withdrawal reactions. study seeks circumvent these drawbacks taking advantage a multifunctional delivery system based on nanoparticles target pathological neuroinflammation. A drug designed generated using mesoporous silica (MSNs) that are loaded with Δ9‐THC (Δ9‐tetrahydrocannabinol, cannabinoid) ARA290 (an erythropoietin‐derived polypeptide), both which possess analgesic anti‐inflammatory functions. actions THC‐MSN‐ARA290 nanocomplexes depend the enhanced permeability retention THC through nanosized carriers, redox‐sensitive release conjugated peptide into local inflammatory milieu. biosafety first evaluated in primary microglia vitro, further mouse model constriction injury. It found attenuate vitro vivo inflammation, achieve sustained relief neuropathic pain injured animals induced thermal hyperalgesia mechanical allodynia. Thus, nanoparticle‐based carrier can be useful for amelioration combinatorial delivery.