Validating Metal‐Organic Framework Nanoparticles for Their Nanosafety in Diverse Biomedical Applications

• DOI: 10.1002/adhm.201600818
• Publication Date: 2016-11-16T18:07:27Z
• Authors: Stefan Wuttke; Andreas Zimpel; Thomas Bein; Simone Braig; Katharina Stoiber; Angelika Vollmar; Dominik Müller; Kirsten Haastert‐...; Jörn Schaeske; Meike Stiesch; Gesa Zahn; Alexander Mohmeyer; Peter Behrens; Oliver Eickelberg; Deniz A. Bölükbas; Silke Meiners
• Keywords: Drug Carriers; Gingiva; Endothelial Cells; Fibroblasts; 01 natural sciences; 0104 chemical sciences; 3. Good health; Mice; metal-organic frameworks; nanoparticles; nanoparticles; nanosafety; drug delivery; nanomedicine; Animals; Humans; Nanoparticles

Metal-organic frameworks (MOFs) are promising platforms for the synthesis of nanoparticles diverse medical applications. Their fundamental design principles allow significant control framework architecture and pore chemistry, enabling directed functionalization nanomedical However, before applying novel nanomaterials to patients, it is imperative understand their potential health risks. In this study, nanosafety different MOF analyzed comprehensively The authors first evaluate effects MOFs on human endothelial mouse lung cells, which constitute a line defense upon systemic blood-mediated local lung-specific applications nanoparticles. Second, we validated these multifunctional surface coatings dental implants using gingiva fibroblasts. Moreover, biocompatibility assessed coating nerve guidance tubes Schwann cells rat dorsal root ganglion cultures. main finding study that principal suitability our as agents drug delivery implant strongly varies with effector cell type. We conclude therefore necessary carefully respect particular application interacting primary types, respectively.