Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs

• DOI: 10.1002/adhm.201701393
• Publication Date: 2018-02-14T07:08:41Z
• Authors: Jianyu Li; Eckhard Weber; Sabine Guth‐Gundel; Michael Schuleit; Andreas Kuttler; Christine Halleux; Nathalie Accart; Arno Doelemeyer; Anne Basler; Bruno Tigani; Kuno Wuersch; Mara Fornaro; Michaela Kneissel; Alexander Stafford; Benjamin R. Freedman; David J. Mooney
• Keywords: Biocompatibility; Protein Adsorption

Abstract Hydrogels are under active development for controlled drug delivery, but their clinical translation is limited by low loading capacity, deficiencies in mechanical toughness and storage stability, poor control over the release that often results burst short duration. This work reports a design of composite clay hydrogels, which simultaneously achieve spectrum mechanical, storage, loading/releasing properties to address critical needs from translational perspectives. The nanoparticles provide large surface areas adsorb biological drugs, assemble into microparticles physically trapped within toughen hydrogel networks. hydrogels demonstrate feasibility extended quantities an insulin‐like growth factor‐1 mimetic protein (8 mg mL −1 ) four weeks. rate primarily governed ionic exchange can be upregulated pH, typical injured tissues. A rodent model Achilles tendon injury used allow highly localized drugs vivo, while demonstrating biodegradation biocompatibility. These attributes make promising system delivery regenerative medicine.