Supramolecular Nanofibers of Drug‐Peptide Amphiphile and Affibody Suppress HER2+ Tumor Growth

• DOI: 10.1002/adhm.201800899
• Publication Date: 2018-10-10T06:13:28Z
• Authors: Chunhui Liang; Lushuai Zhang; Wene Zhao; Linlin Xu; Yaoxia Chen; Jiafu Long; Fuqiang Wang; Ling Wang; Zhimou Yang
• Keywords: Mice, Inbred BALB C; Cell Survival; Recombinant Fusion Proteins; Optical Imaging; Transplantation, Heterologous; Nanofibers; Mice, Nude; Antineoplastic Agents; Hydrogels; 01 natural sciences; 3. Good health; 0104 chemical sciences; Mice; Cell Line, Tumor; Neoplasms; Animals; Humans; Female; Amino Acid Sequence; Peptides

Abstract Antibody‐based medicines and nanomedicines are very promising for cancer therapy due to the high specificity efficacy of antibodies. However, antibody‐drug conjugates antibody‐modified nanomaterials frequently suffer from low drug loading loss functions covalent modification antibody. A novel versatile strategy prepare supramolecular by coassembly an affibody (antiHER2) drug‐peptide amphiphiles is reported here. During enzyme‐instructed self‐assembly process, amphiphile can coassemble with affibody, resulting in nanofibers hydrogels. The (>30 wt%), stability antiHER2 significantly improved at 37 °C (>15 d vitro). exhibit affinity HER2+ cells be efficiently taken up these cells. In a mouse tumor model, abolish NCI‐N87 growth good accumulation retention tumor. This study provides specificity.