Elastic 3D‐Printed Hybrid Polymeric Scaffold Improves Cardiac Remodeling after Myocardial Infarction

• DOI: 10.1002/adhm.201900065
• Publication Date: 2019-04-03T07:01:02Z
• Authors: Yang Yang; Dong Lei; Shixing Huang; Qi Yang; Benyan Song; Yifan Guo; Ao Shen; Zhize Yuan; Sen Li; Feng‐Ling Qing; Xiaofeng Ye; Zhengwei You; Qiang Zhao
• Keywords: Ventricular remodeling; 3d printed; Biocompatibility

Myocardial remodeling, including ventricular dilation and wall thinning, is an important pathological process caused by myocardial infarction (MI). To intervene in this process, a new type of cardiac scaffold composed thermoset (poly-[glycerol sebacate], PGS) thermoplastic (poly-[ε-caprolactone], PCL) directly printed employing fused deposition modeling 3D-printing technology. The PGS-PCL possesses stacked construction with regular crisscrossed filaments interconnected micropores exhibits superior mechanical properties. In vitro studies demonstrate favorable biodegradability biocompatibility the scaffold. When implanted onto infarcted myocardium, improves preserves heart function. Furthermore, several vital aspects remodeling. On morphological level, reduces thinning attenuated infarct size, on cellular it enhances vascular density increases M2 macrophage infiltration, which might further contribute to mitigated apoptosis rate. Moreover, flexible can be tailored any desired shape, showing promise for annular-shaped restraint device application meeting demands minimal invasive operation. Overall, study demonstrates therapeutic effects versatile applications novel 3D-printed, biodegradable biocompatible scaffold, represents promising strategy improving remodeling after MI.