Reactive Oxygen Species‐Scavenging Scaffold with Rapamycin for Treatment of Intervertebral Disk Degeneration

• DOI: 10.1002/adhm.201901186
• Publication Date: 2019-12-10T13:23:32Z
• Authors: Jinyu Bai; Yingzi Zhang; Qin Fan; Jialu Xu; Huajian Shan; Xiang Gao; Qingle Ma; Lei Sheng; Xin Zheng; Weinan Cheng; Dazhuang Li; Mingchao Zhang; Yu Hao; Liangzhu Feng; Qian Chen; Xiaozhong Zhou; Chao Wang
• Keywords: Intervertebral disk; Degeneration (medical)

Abstract The chronic inflammatory microenvironment is characterized by the elevated level of reactive oxygen species (ROS). Here, it hypothesized that developing an ROS‐scavenging scaffold loaded with rapamycin (Rapa@Gel) may offer a new strategy for modulating local to improve intervertebral disk tissue regeneration. therapeutic consisting ROS‐degradable hydrogel can be injected into injured degeneration site (IVD) and release therapeutics in programmed manner. ROS scavenged reduces responses. It found when rats are treated Rapa@Gel, this results increase percentage M2‐like macrophages decrease M1‐like environment, respectively. Regeneration IVD achieved Rapa@Gel treatment, due increased M2 reduced inflammation. This extended treatment many other diseases.