A Novel Anti‐Coagulative Nanocomplex in Delivering miRNA‐1 Inhibitor Against Microvascular Obstruction of Myocardial Infarction

• DOI: 10.1002/adhm.201901783
• Publication Date: 2020-04-27T07:46:47Z
• Authors: Ting Hong; Yazhong Wei; Xiaomei Xue; Yongyong Li; Haiqing Dong; Xiaoyu Guo; Xueyin Shi; Bin He
• Keywords: Coagulative necrosis; Nanocarriers; Serpin

Abstract Great progress has been made in miRNA nanodelivery for the treatment of myocardial infarction (MI). However, within infarct is impeded by microvascular obstruction as a local circulatory disorder caused microthrombus formation microvessels. Knowing that low molecular weight heparin (LMWH) can effectively prevent microcirculation, it hypothesized whether surface modification nanocarrier with LMWH overcome area better delivery. Herein, novel nanocomlex consisting dendrigraft poly‐ l ‐lysine (DGL)‐loaded miR‐1 inhibitor core to decrease apoptosis cardiomyocytes and shell developed. The results show this anti‐coagulative able reduce microvessels inhibit blood‐coagulation factor Xa, thereby overcoming area. In addition, further enhances uptake decreases myocardiocyte apoptosis, thus improving cardiac function attenuating fibrosis. conclusion, DGL‐loaded helps delivering drug area, providing promising therapeutic strategy achieving outcome MI.