Fe‐Doped Polyoxometalate as Acid‐Aggregated Nanoplatform for NIR‐II Photothermal‐Enhanced Chemodynamic Therapy

• DOI: 10.1002/adhm.202000005
• Publication Date: 2020-03-17T14:31:45Z
• Authors: Yunhao Shi; Jiaojiao Zhang; Han Huang; Changyu Cao; Jiajia Yin; Wenjing Xu; Wenjun Wang; Xuejiao Song; Yewei Zhang; Xiaochen Dong
• Keywords: Polyoxometalate

Abstract The combination of reactive oxygen species‐involved chemodynamic therapy (CDT) and photothermal (PTT) holds great promise in enhancing anticancer effects. Herein, a multifunctional Fe‐doped polyoxometalate (Fe‐POM) cluster is fabricated via simple method. Fe‐POM can not only be utilized as PTT agents to generate hyperthermia effect for cancer cell killing under near‐infrared (NIR) II laser (1060 nm) irradiation, but also used CDT convert endogenous less‐reactive H 2 O into harmful ·OH simultaneously deplete glutathione an amplified effect. Notably, the induced by further enhance effect, achieving synergistic PTT/CDT Owing self‐assembling properties at lowered pH values, exhibits high tumor accumulation revealed photoacoustic imaging. More importantly, enables effective destruction tumors without inducing noticeable damage normal tissues 1060 nm irradiation. work presents new type agent with efficacy, providing promising methods PTT‐enhanced NIR‐II biowindow.