Bioactive MOFs Based Theranostic Agent for Highly Effective Combination of Multimodal Imaging and Chemo‐Phototherapy

• DOI: 10.1002/adhm.202000205
• Publication Date: 2020-06-17T06:05:33Z
• Authors: Yuda Zhu; Nini Xin; Zi Qiao; Suping Chen; Lingwan Zeng; Yusheng Zhang; Dan Wei; Jing Sun; Hongsong Fan
• Keywords: Multimodal therapy

Bioactive metal-organic frameworks (bio-MOFs) built from biofunctional metal ions and linkers show a new strategy to construct multifunctional theranostic platforms. Herein, bio-MOF is synthetized via the self-assembling of Fe3+ doxorubicin hydrochloride (DOX) molecules. Then, through stepwise assembly strategy, another bio-MOFs structure consisting Gd3+ 1,3,5-benzenetricarboxylic acid (H3 BTC) wrapped on surfaces Fe-DOX nanoparticles, followed by adsorbing photosensitizer indocyanine green (ICG). Specifically, Gd-MOF shell can not only act as contrast agent for magnetic resonance imaging (MRI), but also provides protection cores, controlling release DOX. The photoacoustic photothermal (PAI PTI) methods are successfully introduced platform loading ICG, providing potential applications multimodal biological imaging. in vitro vivo outcomes indicate that Fe-DOX@Gd-MOF-ICG nanoplatform exhibits outstanding synergistic antitumor performance MR/PA/PT guided chemotherapy, photodynamic combination therapy. work may encourage further exploration based platforms compound therapy, which will open an avenue MOFs toward applications.