Synergistic Antimicrobial Titanium Carbide (MXene) Conjugated with Gold Nanoclusters

• DOI: 10.1002/adhm.202001007
• Publication Date: 2020-09-03T07:29:38Z
• Authors: Kaiyuan Zheng; Shuo Li; Lin Jing; Po‐Yen Chen; Jianping Xie
• Keywords: Nanoclusters; Titanium carbide; MXenes; Gold alloys

Bacterial resistance toward antibiotics is a world-wide problem, and one potential solution to fight against the develop multi-mechanism antimicrobial agents achieve synergistic performance. Titanium carbide (MXene) an emerging 2D nanomaterial with ability physically damage bacterial membrane chemically induce oxidative stress, it can be further conjugated nanomaterials improve its antibacterial Herein, agent developed through conjugation of ultra-small gold nanoclusters (AuNCs) on MXene nanosheets. The AuNCs are effectively delivered into bacteria after caused by MXene, generating localized reactive oxygen species (ROS) high concentration oxidize lipid for enhanced broken, as well DNA violent fragmentation. Thus, physical (via MXene) chemical AuNCs) mechanisms lead eventual death both Gram-positive Gram-negative bacteria, low IC50 values 11.7 µg mL-1 0.04 µm AuNCs. Moreover, crumpled MXene-AuNCs structure constructed inhibit biofilm formation, which hold conjugation, hydrophobic surface prevent attachment, large area containing higher density bactericides.