Biomimetic Silk Fibroin Hydrogels Strengthened by Silica Nanoparticles Distributed Nanofibers Facilitate Bone Repair

• DOI: 10.1002/adhm.202001646
• Publication Date: 2021-03-11T07:37:17Z
• Authors: Yuet Cheng; Gu Cheng; Congyong Xie; Chengcheng Yin; Xiangyang Dong; Zhi Li; Xue Zhou; Qun Wang; Hongbing Deng; Zubing Li
• Keywords: Fibroin

Abstract Various materials are utilized as artificial substitutes for bone repair. In this study, a silk fibroin (SF) hydrogel reinforced by short silica nanoparticles (SiNPs)‐distributed‐silk nanofibers (SiNPs@NFs), which exhibits superior osteoinductive property, is fabricated treating defects. SF acts the base part of composite scaffold to mimic extracellular matrix (ECM), organic component native bone. The distribution SiNPs clusters within partially mimics mineral crystals ECM. Incorporation SiNPs@NFs enhances mechanical properties hydrogel. addition, provides biocompatible microenvironment cell adhesion, proliferation, and osteogenic differentiation in vitro. vivo studies confirm that successful repair achieved with formation large amount new large‐sized cranial defects treated conclusion, SiNPs@NFs‐reinforced‐hydrogel study has potential use tissue engineering.