Mechanobiological Interactions between Dynamic Compressive Loading and Viscoelasticity on Chondrocytes in Hydrazone Covalent Adaptable Networks for Cartilage Tissue Engineering

• DOI: 10.1002/adhm.202002030
• Publication Date: 2021-03-19T06:04:39Z
• Authors: Benjamin M. Richa...; Cierra J. Walker; Mollie M. Maples; Mark A. Randolph; Stephanie J. Bryant; Kristi S. Anseth
• Keywords: Hydrazone; Chondrogenesis

Mechanobiological cues influence chondrocyte biosynthesis and are often used in tissue engineering applications to improve the repair of articular cartilage load-bearing joints. In this work, biophysical effects an applied dynamic compression on chondrocytes encapsulated viscoelastic hydrazone covalent adaptable networks (CANs) is explored. Here, CANs exhibit loss tangents ranging from (9.03 ± 0.01) 10