Bone Replacement: The Secretome of Hypoxia Conditioned hMSC Loaded in a Central Depot Induces Chemotaxis and Angiogenesis in a Biomimetic Mineralized Collagen Bone Replacement Material (Adv. Healthcare Mater. 2/2020)

• DOI: 10.1002/adhm.202070005
• Publication Date: 2020-01-22T10:39:30Z
• Authors: Mandy Quade; Pina Münch; Anja Lode; Sarah Duin; Corina Vater; Anastasia Gabrielyan; Angela Rösen‐Wolff; Michael Gelinsky
• Keywords: Hypoxia

In article number 1901426 by Anja Lode and co-workers, sustained release of hypoxia-conditioned MSC secretome from a central depot induces directed hBMSC migration angiogenesis in biomimetic mineralized collagen scaffolds. This situ tissue engineering concept is suggested to be cell-free ready-to-use therapeutic solution for accelerated bone defect healing.