Dual‐Cues Laden Scaffold Facilitates Neurovascular Regeneration and Motor Functional Recovery After Complete Spinal Cord Injury

• DOI: 10.1002/adhm.202100089
• Publication Date: 2021-03-19T13:47:11Z
• Authors: Dingyang Liu; He Shen; Yeyu Shen; Ge Long; Xinghui He; Yannan Zhao; Zhiquan Yang; Jianwu Dai; Xing Li
• Keywords: Glial scar; Neurite

Complete transection spinal cord injury (SCI) severely disrupts the integrity of both neural circuits and microvasculature system. Hence, fabricating a functional bio-scaffold that could coordinate axonal regeneration vascular reconstruction in lesion area may emerge as new paradigm for complete SCI repair. In this study, photosensitive hydrogel scaffold loaded with collagen-binding stromal cell-derived factor-1a Taxol liposomes is capable inducing migration endothelial cells promoting neurite outgrowth neurons vitro. addition, when implanted into rat T8 model, above dual-cues laden exhibits synergistic effect on facilitating axon vessel within 10 days after injury. Moreover, long-term therapeutic effects are also observed implantation, including revascularization, descending propriospinal regeneration, fibrotic scar reduction, electrophysiological recovery, motor function improvement. summary, has good clinical application potential patients severe SCI.