Dual‐Cues Laden Scaffold Facilitates Neurovascular Regeneration and Motor Functional Recovery After Complete Spinal Cord Injury
Glial scar
Neurite
DOI:
10.1002/adhm.202100089
Publication Date:
2021-03-19T13:47:11Z
AUTHORS (9)
ABSTRACT
Complete transection spinal cord injury (SCI) severely disrupts the integrity of both neural circuits and microvasculature system. Hence, fabricating a functional bio-scaffold that could coordinate axonal regeneration vascular reconstruction in lesion area may emerge as new paradigm for complete SCI repair. In this study, photosensitive hydrogel scaffold loaded with collagen-binding stromal cell-derived factor-1a Taxol liposomes is capable inducing migration endothelial cells promoting neurite outgrowth neurons vitro. addition, when implanted into rat T8 model, above dual-cues laden exhibits synergistic effect on facilitating axon vessel within 10 days after injury. Moreover, long-term therapeutic effects are also observed implantation, including revascularization, descending propriospinal regeneration, fibrotic scar reduction, electrophysiological recovery, motor function improvement. summary, has good clinical application potential patients severe SCI.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (61)
CITATIONS (27)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....