NIR‐Responsive Ti3C2 MXene Colloidal Solution for Curing Purulent Subcutaneous Infection through the “Nanothermal Blade” Effect

• DOI: 10.1002/adhm.202100392
• Publication Date: 2021-05-29T14:41:40Z
• Authors: Xiaolan Wang; Mengyu Yao; Limin Ma; Peng Yu; Teliang Lu; Luhui Zhang; Xinyuan Yuan; Yu Zhang; Jiandong Ye
• Keywords: Titanium; 0301 basic medicine; Mice; 03 medical and health sciences; Animals; 3. Good health

Abstract Pathogenic microorganisms’ infections have always been a difficult clinical challenge and lead to serious health problems. Thus, new strategy is urgently needed. In this study, simple preparation method for Ti 3 C 2 MXene colloidal solution proposed. vitro, Staphylococcus aureus treated with 250 µg mL −1 of under 5 min 808 nm near‐infrared (NIR) laser irradiation twice. eliminated by the “nanothermal blade” effect from combined NIR; antibacterial rate 99%, which higher than pure alone 78%. The mechanism underlying treatment may be that thermal nanosheets first transfer heat cell membrane, disrupting membrane structure, disturbing metabolism causing leakage bacterial protein deoxyribonucleic acid, consequently leading death. vivo results indicate NIR can effectively kill prevent inflammation. Moreover, nontoxic mouse organs during therapeutic process. Therefore, an ideal candidate subcutaneous infection application. proposed in study aids investigation other MXenes as agents.