Conjugate Electrospun 3D Gelatin Nanofiber Sponge for Rapid Hemostasis

• DOI: 10.1002/adhm.202100918
• Publication Date: 2021-07-08T08:36:52Z
• Authors: Xianrui Xie; Dan Li; Yujie Chen; Yihong Shen; Fan Yu; Wei Wang; Zhengchao Yuan; Yosry Morsi; Jinglei Wu; Xiumei Mo
• Keywords: Gelatin; Biocompatibility; Electrospinning; Gelatin sponge

Abstract Developing an excellent hemostatic material with good biocompatibility and high blood absorption capacity for rapid hemostasis of deep non‐compressible hemorrhage remains a significant challenge. Herein, novel conjugate electrospinning strategy to prepare ultralight 3D gelatin sponge consisting continuous interconnected nanofibers. This unique fluffy nanofiber structure endows the low density, surface area, compressibility, ultrastrong liquid capacity. In vitro assessments show has cytocompatibility, cell permeability, hemolysis ratio. The rat subcutaneous implantation studies demonstrate biodegradability sponge. Gelatin aggregates activates platelets in large quantities accelerate formation platelet embolism, simultaneously escalates other extrinsic intrinsic coagulation pathways, which collectively contribute its superior vivo on ear artery injury model liver trauma rabbits that rapidly induce stable clots least loss compared membrane, medical gauze, commercial Hence, holds great potential as absorbable agent hemostasis.