A Dual‐Nanozyme‐Catalyzed Cascade Reactor for Enhanced Photodynamic Oncotherapy against Tumor Hypoxia

• DOI: 10.1002/adhm.202101049
• Publication Date: 2021-09-08T10:35:35Z
• Authors: Miaomiao Chen; Jitao Song; Jialong Zhu; Gaobo Hong; Jing An; Erting Feng; Xiaojun Peng; Fengling Song
• Keywords: Hypoxia

Abstract Tumor hypoxia is a typical characteristic of tumor microenvironment (TME), which seriously compromises the therapeutic effect photodynamic therapy (PDT). The development nanozymes with oxygen‐generation ability promising strategy to overcome oxygen‐dependent PDT but remained great challenge. Herein, dual‐nanozymes based cascade reactor HAMF proposed alleviate for enhanced PDT. hollow mesoporous silica nanoparticles (HMSNs) are constructed as an excellent nanocarrier load ultra‐small gold (Au NPs) and manganese dioxide (MnO 2 ) shell via in situ reduction method, further coordination efficient photosensitizer 4‐DCF‐MPYM (4‐FM), thermally activated delayed fluorescence (TADF) fluorescein derivative. With response TME, MnO can catalyze endogenous H O into subsequently accelerating glucose oxidation by Au NPs produce additional , reversely used substrate ‐catalyzed reaction, thereby constantly producing singlet oxygen ( 1 upon light irradiation. This work on dual‐nanozyme relieve effective suppression, may enrich application multi‐nanozymes biomedicine.